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BACKGROUND: Both genetic and environmental factors are involved in the etiology of osrs gold bipolar disorder; however, biological markers for the transmission of the bipolar genotype ("endophenotypes") have not been found. Autoimmune thyroiditis with raised levels of thyroperoxidase antibodies (TPO Abs) is related to bipolar disorder and may be such an endophenotype. This study was intended to examine whether autoimmune thyroiditis is related to the disease itself, to the (genetic) vulnerability to develop bipolar disorder, or both.
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We required that the components subsumed under the definition of major adverse cardiovascular events were sensitive and unbiased measurable events of the same underlying disease process. We excluded studies reporting only all cause mortality because of the high likelihood of bias by events without an underlying cardiovascular cause. Studies reporting only composite end points, including the clinician driven proxy outcomes of revascularisation or admission to hospital, were excluded because of uncertainties about precision, reproducibility, correlation with clinical end points, the use of non standardised definitions, and a high risk of reporting bias.23 24Studies of patients who underwent percutaneous coronary intervention and reporting definite stent thrombosis events were eligible if the stent thrombosis was evaluated according to the definition from the Academic Research Consortium.25 Probable stent thrombosis was considered only if definite and probable stent thrombosis were reported as a composite outcome.
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